Expedition's card pool is regularly updated. With each expansion set's release, the format's legal sets, Draft Pack contents, and Expedition Archives are revised. Between large sets, cards are added to the format as new campaigns, bundle sets, and promo cards are released, and the Draft Packs and Expedition Archives may be updated with more cards.
| Format | Date | Card Pool/Update |
|---|---|---|
| Dark Frontier | July 1, 2019 | The Empty Throne, Defiance, and Dark Frontier |
| August 5, 2019 | The Trials of Grodov added | |
| The Flame of Xulta | October 7, 2019 | The Flame of Xulta, Draft Pack contents (remade), and select promos |
| November 19, 2019 | The Expedition Archives added (with Dead Reckoning, The Trials of Grodov, and select promo cards) | |
| December 2, 2019 | Draft Pack contents updated (40 new cards) | |
| December 19, 2019 | Promises by Firelight added | |
| February 4, 2020 | Draft Pack contents updated—65 select Echoes of Eternity preview cards added in the set's Draft Preview | |
| Echoes of Eternity | February 11, 2020 | Echoes of Eternity, The Flame of Xulta, Promises by Firelight, and Draft Pack contents (remade) |
| March 11, 2020 | The Tale of Horus Traver added | |
| March 30, 2020 | Whispers of the Throne added, and Draft Pack contents updated (20 new cards) | |
| May 4, 2020 | Shadow of the Spire added | |
| May 12, 2020 | Draft Pack contents updated (73 new cards) | |
| June 17, 2020 | Draft Pack contents updated—63 select Argent Depths preview cards added in the set's Draft Preview | |
| Argent Depths | June 24, 2020 | Argent Depths, Shadows of the Spire, Whispers of the Throne, Echoes of Eternity, Draft Pack contents (remade), and the Expedition Archives (select promo cards) |
| August 10, 2020 | Draft Pack contents updated (73 new cards) | |
| September 1, 2020 | Awakening added | |
| November 2, 2020 | Draft Pack contents updated (56 new cards) | |
| November 4, 2020 | Bastion Rising added | |
| December 12, 2020 | Draft Pack contents updated—61 select Empire of Glass preview cards added in the set's Draft Preview | |
| Empire of Glass | December 14, 2020 | Empire of Glass, Bastion Rising, Awakening, Argent Depths, Draft Pack contents (remade), and the Expedition Archives (select promo cards) |
| January 8, 2021 | Draft Pack contents updated (10 new cards) | |
| February 11, 2021 | Buried Memories added | |
| February 24, 2021 | Draft Pack contents updated (84 new cards) | |
| March 23, 2021 | Stormbreak added | |
| April 20, 2021 | Draft Pack contents updated (28 new cards) | |
| May 10, 2021 | Draft Pack contents updated—61 select Revelations preview cards added in the set's Draft Preview | |
| Revelations | December 14, 2020 | Revelations, Stormbreak, Buried Memories, Empire of Glass, Draft Pack contents (remade), and the Expedition Archives (select promo cards) |